Multi-Omics Stratification in Precision Oncology

This review examines multi-omics stratification in precision oncology. The organizing question is which integration and validation steps convert molecular patterns into reproducible treatment-relevant strata. Ten related scholarly sources are synthesized through a decision-centered framework spanning problem definition, mechanism, measurement, evaluation, implementation, and governance. The review does not invent experiments, pooled estimates, or unreported quantitative results. It instead evaluates the strength and transferability of the available evidence, with particular attention to deriving clinically precise claims from high-dimensional exploratory clusters. The resulting framework links technical or empirical performance to explicit use conditions and identifies tests that should precede wider adoption in precision oncology and biomarker-guided care.

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